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Reunión de Usuarios y Desarrolladores de Métodos de Simulación de Aragón

ZCAM-Daresbury Laboratory collaborative tutorial: Computational methods for macromolecular phasing and refinement

Prof. Garib Murshudov, MRC Laboratory of Molecular Biology
Prof. Isabel Uson, ICREA at Consejo Superior de Investigaciones Cientificas
Prof. Martyn Winn, STFC Daresbury Laboratory

DATE OF EVENT : 11/03/2012       DURATION : 6 day(s)

LOCATION : ZCAM Campus Actur C/ Mariano Esquillor s/n Edificio I+D 50018 Zaragoza


SUMMARY :

The overall objective of this course is to provide an intensive practical training in all computational aspects of macromolecular structure elucidation by X ray diffraction techniques, for advanced graduate students and postdoctoral researchers.

At the end of the course, the students should have gained basic abilities to:
1. Process X ray diffraction data and assess their quality
2. Understand and use all the main current methods to solve the phase problem
3. Understand the choices to be met in terms of parameterization, target functions and algorithms during refinement and practice with the most widely used software.
4. Discuss and exercise validation to assess the quality of the resulting atomic models and the information content of a crystallographic analysis.
5. Use visualization programs to build and analyze the atomic models in terms of protein folding, interatomic distances and surface interactions.
In order to achieve these specific goals, established, state-of-the-art software will be employed under the guidance of its developers, whenever applicable with experimental data from the student's own projects or laboratories.

The Instructors have all been involved in software development for macromolecular crystallography for many years, and represent the leaders in the field in Europe and the world. They are also regular tutors for these kind of schools, and understand how to relate difficult concepts to the average biologist.

The workshop is primarily funded by the Zaragoza and Daresbury CECAM nodes. Additional support is provided by CCP4 and the supercomputing centre FCSC.

Applying for the course

The number of 'students' will be limited to 28. Thanks to generous support from the CECAM nodes, we are able to provide accommodation (2 to a room) and some meals. Students are responsible for their own travel. The closing date for applications is February 3rd 2012.

Application is via the Ask/Apply tab. You should include in the message your name, M or F, brief details of your academic qualifications and of your research project, including (very briefly) results achieved so far as well as problems with phasing and/or refinement, the name of your reseach supervisor or other person who may be consulted if necessary. All this information will be treated confidentially. Participants are encouraged to bring their own data.